Xultophy^® 100/3.6 may cause serious side effects, including:

• Possible thyroid tumors, including cancer. Tell your health care provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats and mice, liraglutide, one of the components of Xultophy^® 100/3.6, and medicines that work like liraglutide caused thyroid tumors, including thyroid cancer. It is not known if Xultophy^® 100/3.6 will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people.

Xultophy^® 100/3.6 (insulin degludec and liraglutide) injection 100 units/mL and 3.6 mg/mL is an injectable prescription medicine that contains 2 diabetes medicines, insulin degludec, 100 units/mL, and liraglutide, 3.6 mg/mL, that is used along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes

• Xultophy^® 100/3.6 is not recommended as the first choice of medicine for treating diabetes.
• Xultophy^® 100/3.6 is not recommended for people who take liraglutide or other medicines called glucagon like peptide 1 receptor agonists (GLP-1 RA).
• Xultophy^® 100/3.6 is not for use in people with diabetic ketoacidosis (increased ketones in the blood or urine).
• It is not known if Xultophy^® 100/3.6 can be used with mealtime insulin.
• It is not known if Xultophy^® 100/3.6 is safe and effective for use in children.

Do not use Xultophy^® 100/3.6 if:

• you or any of your family have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
• you are having an episode of low blood sugar
• if you are allergic to insulin degludec, liraglutide, or any of the ingredients in Xultophy^® 100/3.6. See symptoms of serious allergic reaction in “What are the possible side effects of Xultophy^® 100/3.6?”

Tell your health care provider about all your medical conditions, including if you:

• have or have had problems with your pancreas.
• have heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs (thiazolidinediones) with Xultophy^® 100/3.6.
• have severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems with digesting food.
• are taking certain medicines called GLP-1 receptor agonists.
• are scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation).
• are pregnant or breastfeeding or plan to become pregnant or breastfeed. It is not known if Xultophy^® 100/3.6 will harm your unborn baby or if Xultophy^® 100/3.6 passes into your breast milk.

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Before using Xultophy^® 100/3.6, talk to your health care provider about low blood sugar and how to manage it.

• Read the Instructions for Use and take Xultophy^® 100/3.6 exactly as your health care provider tells you.
• Do not change your dosing schedule without first talking to your health care provider.
• Do not inject Xultophy^® 100/3.6 into a muscle or vein or use in an insulin infusion pump.
• Use Xultophy^® 100/3.6 at the same time each day with or without food. Do not take more than 50 units of Xultophy^® 100/3.6 each day.
• Check the Pen label each time you give your injection to make sure you are using the correct medicine.
• Change (rotate) your injection sites within the area you choose with each injection to reduce your risk of getting lipodystrophy (pits in skin or thickened skin) and localized cutaneous amyloidosis (skin with lumps) at the injection sites.
  
  • Do not use the exact same spot for each injection.
  • Do not inject where the skin has pits, is thickened, or has lumps.
  • Do not inject where the skin is tender, bruised, scaly or hard, or into scars or damaged skin.
• Do not share your Xultophy^® 100/3.6 pen with other people, even if the needle has been changed. You may give other people a serious infection, or get a serious infection from them.
• Check your blood sugar levels. Ask your health care provider what your blood sugar levels should be and when you should check them.

• Do not drive or operate heavy machinery, until you know how Xultophy^® 100/3.6 affects you. Do not drink alcohol or use prescription or over-the-counter medicines that contain alcohol.

Xultophy^® 100/3.6 may cause serious side effects that can be life-threatening, including:

• inflammation of your pancreas (pancreatitis). Stop using Xultophy^® 100/3.6 and call your health care provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without nausea or vomiting. Sometimes you may feel the pain from your abdomen to your back.
• low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Xultophy^® 100/3.6 with another medication that can cause low blood sugar. Signs and symptoms of low blood sugar may include: dizziness or light-headedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling jittery.
• dehydration leading to kidney problems. Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration. Tell your healthcare provider right away if you have nausea, vomiting, or diarrhea that does not go away.
• severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Xultophy^® 100/3.6. Tell your healthcare provider if you have stomach problems that are severe or will not go away.
• serious allergic reactions. Stop using Xultophy^® 100/3.6 and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue or throat, problems breathing or swallowing, sudden coughing, chest pain or tightness, hives, rash, itching, fast heartbeat, or fainting or feeling dizzy.
• gallbladder problems. Gallbladder problems have happened in some people who take liraglutide, an ingredient in Xultophy^® 100/3.6. Tell your health care provider right away if you get symptoms of gallbladder problems including pain in the right or middle upper stomach area, fever, yellowing of skin or eyes (jaundice), or clay-colored stools.
• low potassium in your blood (hypokalemia).
• heart failure. Taking certain diabetes medicines called TZDs with Xultophy^® 100/3.6 may cause heart failure in some people. This can happen even if you have never had heart failure or heart problems. If you already have heart failure, it may get worse while you take TZDs with Xultophy^® 100/3.6. Tell your health care provider if you have any new or worse symptoms of heart failure, including shortness of breath, tiredness, swelling of your ankles or feet, and sudden weight gain.
• food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Xultophy^® 100/3.6 may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Xultophy^® 100/3.6 before you are scheduled to have surgery or other procedures.

The most common side effects of Xultophy^® 100/3.6 may include stuffy or runny nose, sore throat, headache, nausea, diarrhea, increased blood levels of lipase, and upper respiratory tract infection.