- Using estrogen-alone may increase your chance of getting cancer of the uterus (womb).
- Report any unusual vaginal bleeding right away while you are using Vagifem®. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
- Do not use estrogen-alone to prevent heart disease, heart attacks, strokes, or dementia (decline in brain function).
- Using estrogen-alone may increase your chances of getting strokes or blood clots.
- Using estrogen-alone may increase your chance of getting dementia, based on a study of women 65 years of age and older.
- Do not use estrogens with progestogens to prevent heart disease, heart attack, strokes, or dementia.
- Using estrogens with progestogens may increase your chances of getting blood clots, strokes, heart attacks, or breast cancer.
- Using estrogens with progestogens may increase your chance of getting dementia, based on a study of women 65 years of age and older
- Only one estrogen-alone product and dose have been shown to increase your chances of getting strokes, blood clots, and dementia. Only one estrogen with progestogen product and dose have been shown to increase your chances of getting heart attacks, strokes, breast cancer, blood clots, and dementia.
- Because other products and doses have not been studied in the same way, it is not known how the use of Vagifem® will affect your chances of these conditions. You and your healthcare provider should talk regularly about whether you still need treatment with Vagifem®.